Are statins overprescribed?

Are statins anti-inflammatory?

Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. Emerging evidence from both clinical trials and basic science studies suggest that statins have anti-inflammatory properties, which may additionall...

Statins in Chronic Kidney Disease- Are Statins Really Renoprotective

Numerous trials have shown that chronic kidney disease increases the risk of cardiovascular disease. Dyslipidemias have been shown to accelerate progression of kidney disease. Statins have assumed a pivotal role in management of hyperlipidemia. However their effect on renal function is still not fully understood. Some clinical trials have shown some renoprotective effect of statins but there is...

Statins are diabetogenic--myth or reality?

Multiple clinical trials have demonstrated the beneficial effects of statins in lowering levels of low-density lipoprotein and in the prevention of cardiovascular disease. However, although statins have a good safety profile, a debate has been ongoing as to whether use of statins increases risk of new-onset diabetes. Recent large scale meta-analyses of statin trials support the concept of a dia...

Are statins a remedy for all seasons?

Are statins failing in heart failure?

Statins are a well-established treatment for primary and secondary prevention of atherosclerotic cardiovascular disease. They have been shown to slow and even reverse the development of coronary and cerebral atherosclerosis and to improve outcomes in non-heart failure (HF) patients with ischaemic heart disease. Moderate doses of statins reduce the incidence of major vascular events by 20% for e...